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KMID : 0365819740140010213
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Journal of Pusan Medical College
1974 Volume.14 No. 1 p.213 ~ p.219
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The Effect of N-ethylmaleimade on the Potassium Permeability in the Rabbit Erythrocyte Membrane
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Abstract
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This study was undertaken to investigate the effect of N-ethylmaleimide on the potassium permeability of the rabbit erythrocyte membrane. The results are summarized as follows.
1. N-ethylmaleimide causes the efflux of K+ on the rabbit erythrocyte membrane. The K+ efflux progresses rapidly for about 60 minutes, and slows down thereafter.
2. Osmotic resistance of N-ethylmaleimide-treated erythrocytes is diminished. Blood plasma, albumin or dextrose prevents diminution of osmotic resistance of erythrocytes induced by N-ethylmaleimide.
3. The K+ efflux induced by N-ethylmaleimide is markedly inhibited by addition of cysteine or glutathione in the incubation medium while dinitrophenol or oligomycin has little influence on the efflux of K+ by N-ethylmaleimide.
4. EDTA or p-chloromercuribenzoate (PCMB). promotes slightly the K+ efflux by N-ethylmaleimide.
5. lodoacetate causes the efflux of K+ less than N-ethylmaleimide whereas PCMB causes the K+ efflux more than N-ethylmaleimide.
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KEYWORD
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